omicron hospitalization rate vaccinated by age

Suggested citation for this article: Taylor CA, Whitaker M, Anglin O, et al. Risk of reinfection, vaccine protection, and severity of infection with Omicron data in UK is 'enormously worrying,' immunologist says "In the last two weeks, no fewer than 80% of admissions were below the age of 50 years. Nature Communications (Nat Commun) We did not assess whether vaccines received before pregnancy or immediately after pregnancy were associated with a reduced risk of testing positive for SARS-CoV-2 in infants. TN, NMF, SFlax, SFunk, SA, SB, and ST did the formal analysis. J. Med. Still, even with a smaller percentage of people getting severely ill during the Omicron wave, a large number of cases over a short time can lead to a spike in people being hospitalized or admitted . Children and COVID-19: state data report. Rates cannot be stratified by pregnancy status because the underlying population of pregnant women in the catchment area is unknown. 41, e81e86 (2022). Messer, L. C. et al. The U.K. Health. Evaluation of acute adverse events after Covid-19 vaccination during pregnancy. endorsement of these organizations or their programs by CDC or the U.S. In the present study, the mothers of only 32% of infants in the cohort received at least 2 doses during pregnancy. We monitored the seroprevalence of SARS-CoV-2 nucleocapsid (anti-N) and spike protein (anti-S) antibodies in blood donors across Canada from September 2021 to June 2022 in 202,123 . volume14, Articlenumber:894 (2023) We used two different study designs: a primary design using a cohort analysis in which infants of vaccinated pregnant persons were compared with infants of unvaccinated pregnant persons. Dis. Our primary cohort analysis used calendar days as the underlying scale to ensure that we compared infants of vaccinated and unvaccinated mothers on the same calendar days because vaccination status during pregnancy and risk of SARS-CoV-2 infection varied over the study period. Atlanta, GA: US Department of Health and Human Services, CDC; 2022. In the meantime, to ensure continued support, we are displaying the site without styles Three recent epidemiological studies found that vaccination during pregnancy was associated with a reduced risk of SARS-CoV-2 infection in infants during their first 4 months of life and a reduced risk of hospitalization during the first 5 months of life17,18,19. Vaccine 40, 656665 (2022). Gordon, N. & Lin, T. The Kaiser Permanente Northern California adult member health survey. From Jan 1 to Mar 16, 2022, when Omicron was predominant, 4,781 (0.02%) of 19,473,570 booster recipients died of COVID-19, and 58,020 (0.3%) died of other causes. Selected counties in California, Colorado, Connecticut, Georgia, Iowa, Maryland, Michigan, Minnesota, New Mexico, New York, Ohio, Oregon, Tennessee, and Utah (https://www.cdc.gov/mmwr/volumes/69/wr/mm6915e3.htm). Thank you for taking the time to confirm your preferences. CDC Charts Show Hospitalization Rates for Unvaxxed, 2 Doses, 3 Doses Additional recommendations followed and data availability on booster-dose status varies by age because not all age groups were recommended by ACIP to receive booster doses at the same time. Additional limitations include the inability to estimate the effectiveness of vaccines received prior to pregnancy onset. Am. Among the infants in the cohort, 19,418 (64.06%) of the mothers were unvaccinated during pregnancy, 1138 (3.75%) of the mothers received one dose of an mRNA COVID-19 vaccine and 9755 (32.18%) received 2 doses during pregnancy (Table1). Article A recent study found that the mean titer of maternally derived antibodies in infants of vaccinated mothers were higher at age 2 months compared with antibody titers at age 6 months23. These cookies may also be used for advertising purposes by these third parties. How the Omicron Surge Is Taxing Hospitals - Healthline We conducted secondary sensitivity analyses restricting the population to infants who received at least one SARS-CoV-2 PCR test. PubMed Central Mothers were classified as either having had 2 doses or one dose of mRNA COVID-19 vaccines during pregnancy (and completed more than 14 days prior to delivery) or not having had any COVID-19 vaccines prior to delivery. NHS Test and Trace statistics (England): methodology. COVID-19 vaccine surveillance report: week 6. B., Lewis. Wkly Rep. 71, 352358 (2022). SARS-CoV-2 delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness. Buchan, S. A. et al. The report found that, during the omicron wave 6,743.5 per 100,000 unvaccinated people were contracting COVID-19 and 187.8 per 100,000 were hospitalized. The rate among adults who received a primary series, but no booster or additional dose, was three times the rate among adults who received a booster or additional dose. During the Omicron dominant period, maternal vaccination with at least two doses reduced the infants risk of testing SARS-CoV-2 positive by 43% (95% CI: 4, 69) during the first 2 months of life, 36% (95% CI:11, 55) during the first 4 months of life, and 41% (95% CI: 25, 53) during the first 6 months of life (Supplemental Table2). TN, NMF, SB, EV, SRS, DDA, and AMP developed the methodology. 9-14 As of October 2022, 68% of the US population has completed primary series vaccination. 386, 15321546 (2022). Risk of hospitalisation associated with infection with SARS-CoV-2 lineage B.1.1.7 in Denmark: an observational cohort study. Kaiser Permanente Northern California, Vaccine Study Center, Oakland, CA, USA, Ousseny Zerbo,G. Thomas Ray,Bruce Fireman,Evan Layefsky,Kristin Goddard,Edwin Lewis,Pat Ross&Nicola P. Klein, Yale University, Institute for Global Health, New Haven, CT, USA, Department of Internal Medicine (Infectious Diseases), Yale School of Medicine, New Haven, CT, USA, Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA, Obstetrics and Gynecology, Kaiser Permanente Northern California Oakland, Oakland, CA, USA, Regional Perinatal Service Center, Kaiser Permanente Northern California, Santa Clara, CA, USA, You can also search for this author in Infants were followed from birth until the first positive SARS-CoV-2 test by PCR at age 2, 4, or 6 months, with censoring due to death, health plan disenrollment, or end of follow-up (May 31, 2022). Estimation of COVID-19 mRNA vaccine effectiveness against medically attended COVID-19 in pregnancy during periods of delta and Omicron variant predominance in the United States. Comparative analysis of the risks of hospitalisation and death Sign up for notifications from Insider! Hospitalization of Infants and Children Aged 0-4 Years with Lab Child hospitalization rates reach record highs amid Omicron's surge During the Omicron-predominant period, overall weekly adult hospitalization rates peaked at 38.4 per 100,000, exceeding the previous peak on January 9, 2021 (26.1) and the peak rate during the Delta-predominant period (15.5) (Figure 1). Among these infants, for our main analysis, we excluded 21,891 (35.2%) based on maternal exclusion criteria and 10,412 (16.8%) after applying infant exclusion criteria (Fig. Implementing strategies that result in the equitable receipt of COVID-19 vaccinations, though building vaccine confidence, raising awareness of the benefits of vaccination, and removing barriers to vaccination access among persons with disproportionately higher hospitalizations rates from COVID-19, including Black adults, is an urgent public health priority. Protection during both periods decreased as infants aged from 2 months to 6 months. These persons are excluded from the proportions of race/ethnicity but are included in other analyses. Moline HL, Whitaker M, Deng L, et al. During the Omicron dominant period, receipt of 2 doses during pregnancy reduced the risk of the infant testing SARS-CoV-2 positive by 21% (95% CI: 21, 48) during the first 2 months of life, 14% (95% CI: 8, 32) during the first 4 months of life, and 13% (95% CI: 3, 26) during the first 6 months of life (Table2). U.S. regulators had authorized the Pfizer/BioNTech COVID-19 vaccine for children aged 5 to 11 years in October, prior to the Omicron surge. Egyptian hemodialysis patients' willingness to receive the COVID-19 Children born at Kaiser Permanente Northern California from December 15, 2020, through May 31, 2022. Age-adjusted rates were calculated by dividing the number of hospitalized COVID-19 patients by population estimates for race/ethnicity, and vaccination status in the catchment area. Hospitalisation associated with SARS-CoV-2 delta variant in Denmark. Razzaghi, H. et al. Starting the week ending December 4, 2021, Maryland data are not included in weekly rate calculations but are included in previous weeks. This preceded and had no relation to COVID-19, and GD had no role in and received no funding from the project. "People who get vaccinated may be more cautious about COVID in general, or perhaps getting vaccinated makes them less cautious, or they may live in states with more/less COVID risk, etc," Jit said. The study had limitations worth noting. Weekly rates among unvaccinated adults and adults who received a primary COVID-19 vaccination series with a booster or additional dose peaked at 149.8 (January 8, 2022) and 11.7 (January 22, 2022), respectively. "The association between the QCovid risk groups and the risk of death were stronger in people who had received a booster and were infected by the Omicron variant compared with evidence from the Alpha and Delta period in doubly vaccinated individuals," the authors wrote. You are using a browser version with limited support for CSS. The images or other third party material in this article are included in the articles Creative Commons license, unless indicated otherwise in a credit line to the material. Pediatr. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. 4% of cases) without NHS numbers were excluded from our primary analysis. T.R. References to non-CDC sites on the Internet are Cookies used to make website functionality more relevant to you. 45 C.F.R. J. The study was funded by the National Institute of Allergy and Infectious Disease grant # 1R01AI168373-01 to O.Z. 40, e137e145 (2021). Vaccines: The CDC recommends that everyone age 5 and older get an updated covid booster shot. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. J., Fireman. URL addresses listed in MMWR were current as of Among nonpregnant and pregnant adults aged 18 years, hospitalization rates were calculated overall, and by race/ethnicity and COVID-19 vaccination status. N. Engl. No other potential conflicts of interest were disclosed. No other exclusion criteria were applied. PubMedGoogle Scholar. Arthur Reingold, Jeremy Roland, Ashley Coates, California Emerging Infections Program, Oakland, California; Breanna Kawasaki, Rachel Herlihy, Isaac Armistead, Madelyn Lensing, Jordan Surgnier, Sarah McLafferty, Colorado Department of Public Health & Environment; Ann Basting, Tessa Carter, Maria Correa, Daewi Kim, Carol Lyons, Hazhia Sorosindi, Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut; Emily Fawcett, Katelyn Ward, Jana Manning, Asmith Joseph, Allison Roebling, Chandler Surell, Stephanie Lehman, Taylor Eisenstein, Suzanne Segler, Grayson Kallas, Marina Bruck, Rayna Ceaser, Annabel Patterson, Sabrina Hendrick, Johanna Hernandez, Hope Wilson, School of Medicine, Emory University, Georgia Emerging Infections Program, Georgia Department of Public Health, Veterans Affairs Medical Center, Foundation for Atlanta Veterans Education and Research, Atlanta, Georgia; Jim Collins, Shannon Johnson, Justin Henderson, Sue Kim, Alexander Kohrman, Lauren Leegwater, Val Tellez Nunez, Sierra Peguies-Khan, Michigan Department of Health and Human Services; Kayla Bilski, Kristen Ehresmann, Richard Danila, Jake Garfin, Grace Hernandez, Kieu My Phi, Ruth Lynfield, Sara Vetter, Xiong Wang, Minnesota Department of Health; Daniel M. Sosin, Susan L. Ropp, Sunshine Martinez, Jasmyn Sanchez, Cory Cline, Melissa Judson, Florent Nkouaga, Mark Montoya, New Mexico Department of Health; Sarah Lathrop, Kathy M. Angeles, Yadira Salazar-Sanchez, Sarah A. Khanlian, Nancy Eisenberg, Dominic Rudin, Sarah Shrum Davis, Mayvilynne Poblete, Emily B. Hancock, Francesca Pacheco, New Mexico Emerging Infections Program; Yassir Talha, Celina Chavez, Jennifer Akpo, Alesia Reed, Murtada Khalifa, CDC Foundation, New Mexico Department of Health; Suzanne McGuire, Kerianne Engesser, Nancy Spina, Adam Rowe, New York State Department of Health; Sophrena Bushey, Virginia Cafferky, Maria Gaitan, Christine Long, Thomas Peer, Kevin Popham, University of Rochester School of Medicine and Dentistry, Rochester, New York; Julie Freshwater, Denise Ingabire-Smith, Ann Salvator, Rebekah Sutter, Ohio Department of Health; Sam Hawkins, Public Health Division, Oregon Health Authority; Tiffanie Markus, Katie Dyer, Karen Leib, Terri McMinn, Danielle Ndi, Gail Hughett, Emmanuel Sackey, Kathy Billings, Anise Elie, Manideepthi Pemmaraju, Vanderbilt University Medical Center, Nashville, Tennessee; Amanda Carter, Andrea George, Andrew Haraghey, Ashley Swain, Caitlin Shaw, Laine McCullough, Mary Hill, Ryan Chatelain, Salt Lake County Health Department, Salt Lake City, Utah; Alvin Shultz, Robert W. Pinner, Rainy Henry, Sonja Mali Nti-Berko, CDC; Elizabeth Daly, Council of State and Territorial Epidemiologists. As of December 25, the rate among unvaccinated people was 78 per 100,000, compared to 4 per 100,000 among fully vaccinated people, the CDC reported. Acosta AM, Garg S, Pham H, et al. 387, 187189 (2022). The Spanish Health Ministry also publishes hospitalization data throughout Spain broken down by vaccination status, although in this case it is based on estimates: to calculate the number of unvaccinated in each age group, they subtract the number of vaccinated from the population in 2020.However, the target population will have grown since then, so it is possible that the ministry's . Evan J. Anderson reports grants from Pfizer, Merck, PaxVax, Micron, Sanofi-Pasteur, Janssen, MedImmune, and GlaxoSmithKline; personal fees from Pfizer, Medscape, Kentucky Bioprocessing, Inc., Sanofi-Pasteur, and Janssen, outside the submitted work; and institutional funding from the National Institutes of Health to conduct clinical trials of Moderna and Janssen COVID-19 vaccines. If the SARS-CoV-2 test date was not available, hospital admission date was used. Vaccine 31, 31043109 (2013). Relative to the Delta-predominant period, a larger proportion of hospitalized Black adults were unvaccinated. The proportion of hospitalized adults who received booster or additional doses increased from 1.3% during the Delta-predominant period to 13.4% during the Omicron-predominant period (p<0.01)***; among these, 10.7% were long-term care facility residents and 69.5% had an immunosuppressive condition. Black adults accounted for 25.2% of all unvaccinated persons hospitalized during the Delta-predominant period; that proportion increased by 23%, to 31.0% during the Omicron-predominant period. Method: This case-control study aims to determine the hospitalization risk associated with the inactivated BBIBP-CorV (Sinopharm) and mRNA BNT162b2 (Pfizer . Fully-vaccinated in this chart meant one dose of the J&J vaccine or two doses of Pfizer or Moderna. According to the CDC, hospitalization rates among the unvaccinated were 16 times higher in December overall. During the period of Omicron predominance, hospitalization rates increased most sharply among Black adults in the United States relative to all other racial and ethnic groups examined and reached the highest rate observed among all racial and ethnic groups since the beginning of the pandemic. Kim, L. et al. Gretchen Rothrock, California Emerging Infections Program; Millen Tsegaye, Colorado Department of Public Health and Environment; Julie Plano, Connecticut Emerging Infections Program, Yale School of Public Health; Kyle Openo, Georgia Emerging Infections Program, Georgia Department of Public Health Division of Infectious Diseases, School of Medicine, Emory University; Andy Weigel, Iowa Department of Health; Chloe Brown, Michigan Department of Health and Human Services; Erica Bye, Minnesota Department of Health; Wickliffe Omondi, New Mexico Emerging Infections Program, University of New Mexico; Alison Muse, New York State Department of Health; Christina Felsen, University of Rochester School of Medicine and Dentistry; Eli Shiltz, Ohio Department of Health; Nasreen Abdullah, Public Health Division, Oregon Health Authority; William Schaffner, Vanderbilt University Medical Center; Melanie Crossland, Salt Lake County Health Department. However, vaccination during pregnancy was less effective at protecting infants against SARS-CoV-2 infection during the Omicron period. Adults who received booster doses were classified as those who completed the primary series and received an additional or booster dose on or after August 13, 2021, at any time after completion of the primary series, and 14 days before a positive test result for SARS-CoV-2, as COVID-19associated hospitalizations are a lagging indicator and time passed after receipt of a booster dose has been shown to be associated with reduced rates of COVID-19 infection (https://www.nejm.org/doi/full/10.1056/NEJMoa2114255).